Metabolic Flexibility, Fasted Cardio & VO₂ Max


I recently joined Nick Shaw on the Renaissance Periodization Podcast for a wide-ranging discussion on metabolic flexibility, fuel systems, and practical strategies for improving body composition and performance.

We dug into how the body switches between carbohydrates and fat as fuel depending on the demands of the activity. High-power efforts rely heavily on carbohydrates because they can generate ATP faster, while lower-intensity work shifts more toward fat metabolism.

We also covered why some popular strategies—like long-term keto followed by carb loading—often fail for performance due to reduced carbohydrate-use capacity. From there, we explored alternatives such as fasting, carb cycling, and using fasted cardio strategically for physique athletes.

Along the way, we talked about the brutal physiology behind 400-meter repeats, Wingate tests, rowing intervals, and why building a larger VO₂ max in the off-season can make future dieting phases easier.

If you’re interested in metabolic flexibility, cardio for lifters, and practical physiology, this was a fun one.

Listen here:

Episode Chapters:

  • 00:00 Welcome and Guest Intro
  • 01:10 Cold Weather Small Talk
  • 02:24 Do We Adapt to Cold05:29 Mike Nelson Background
  • 07:16 Metabolic Flexibility Explained
  • 08:53 Genetics and Endurance Myths
  • 15:27 Training Flexibility Keto and PDH
  • 19:04 Carbs vs Fat and The Burn21:02 Brutal Tests 400s and Wingate
  • 25:34 Fasting and Carb Cycling Strategy
  • 28:51 Fasted Cardio for Physique
  • 32:31 Muscle Loss Concerns and EAAs
  • 35:54 Brad Schoenfeld Study Setup
  • 36:25 Fasted Cardio Study Limits
  • 37:55 Small Edge for Competitors
  • 39:03 Using HRV to Dose Cardio40:44 Personal Fat Loss Playbook
  • 42:39 High Protein Hunger Tradeoffs
  • 44:11 Macros Fat vs Carbs Logic
  • 48:41 Extreme Protein Practicality
  • 53:23 NEAT and Hidden Movement
  • 58:14 Hardgainers and Calorie Creep
  • 01:04:02 VO2 Max for Easier Preps
  • 01:05:45 Muscle Mass and Calorie Burn
  • 01:07:23 Wrap Up and Where to Find Mike

Much love,
Dr Mike

Listen here and let me know what you thought! Share it on the socials and be sure to tag me and RP, thanks!

_____________________

Mike T Nelson CISSN, CSCS, MSME, PhD
Associate Professor, Carrick Institute
Owner, Extreme Human Performance, LLC
Editorial Board Member, STRONG Fitness Mag

Mike T Nelson is a PhD and not a physician or registered dietitian. The contents of this email should not be taken as medical advice. It is not intended to diagnose, treat, cure, or prevent any health problem - nor is it intended to replace the advice of a physician. Always consult your physician or qualified health professional on any matters regarding your health.

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Dr Mike T Nelson

Creator of the Flex Diet Cert & Phys Flex Cert, CSCS, CISSN, Assoc Professor, kiteboarder, lifter of odd objects, metal music lover. >>>>Sign up to my daily FREE Fitness Insider newsletter below

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