I just finished an amazing chat for a future podcast with my buddy Dr. Dan Pardi and we got talking about cell function—and that sparked this email about senolytic supplements.

But first…

Newsflash, Brosky – you can’t out-supplement the basics.

If you have the aerobic capacity of a propranolol’ed possum, get thee to a Concept2 rower before we even talk.

If your “nutrition plan” looks like a Hoover upright sucking up Pop-Tarts, fix that first.

And if your sleep is an afterthought, like spooning a foam roller in the garage gym at 2AM, then you’re building a mansion on a swamp.

Hammer the basics with violent consistency. Then—and only then—can you start messing with bleeding-edge toysZ.

That’s when we roll into esoteric supplements and weird physiological rabbit holes (aka the playground of my Phys Flex Cert—shameless plug, and no, I’m not sorry).

Here’s how I approach it:

• Risk vs reward. If the downside is minimal and the safety data looks good? Worth experimenting.
• If the downside is death (see: DNP, aka Darwin’s favorite fat burner)? Hard pass.

Which brings us to today’s cell-scrubbing curiosity: senolytics.

Sen-a-what?

The term comes from senex (old) + lytic (destroy). Translation: “destroy the old.”

Think of it like firing the useless donut-bringer at Planet Fitness. These senescent cells are old, half-dead, no longer pulling their weight...

..but still showing up every day with pink frosted sabotage. Senolytics clear the deadwood, making room for new, vibrant cells to run the shop.

And here’s where it gets fun: the nerds at Qualia have built a senolytic product that you only take two days in a row, once a month.

That’s it. No daily pill prison. Just a monthly cell cleanse to fire the cellular slackers.

>> Qualia Senolytic <<
Coupon Code: DRMIKE (extra 15% off any order, including subs).

My n=1?

Even on a very low-calorie day with a 2-hour training session before, my HRV didn’t crater the next day.

Felt surprisingly solid. (Insert all the caveats about n=1 and placebo, yada yada—but still interesting).

Three notes before you get frothy:

1. Don’t start here if your basics are garbage. This is supplement sprinkles on the recovery sundae, not the base.
2. Yes, I’m an affiliate. I make some coin if you buy. Transparency is sexy, and you get 15% off with code DRMIKE.
   >> Qualia Senolytic <<
3. Safety data looks good, usage is idiot-proof (2 days, once a month).

If you’re dialed in and want to test the bleeding edge? This is one of the cleaner plays.

Much love and fewer zombie cells,
– Dr. Mike

PS – If you want to go deeper down the physiology rabbit hole, that’s exactly what I built my Phys Flex Cert for. It’s where the basics end and the advanced resilience party begins. Enrollment opens again this October 13. Until then? Fire the donut cells.

>> Qualia Senolytic <<

Coupon Code: DRMIKE (provides an extra 15% off any order, including subscriptions!!)

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Mike T Nelson CISSN, CSCS, MSME, PhD
Associate Professor, Carrick Institute Owner, Extreme Human Performance, LLC Editorial Board Member, STRONG Fitness Mag

Mike T Nelson is a PhD and not a physician or registered dietitian. The contents of this email should not be taken as medical advice. It is not intended to diagnose, treat, cure, or prevent any health problem - nor is it intended to replace the advice of a physician. Always consult your physician or qualified health professional on any matters regarding your health.

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